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Target intelligence / Profile preview
MHC class I chain-related proteins A and B (MICA/B)
- Target
- MICA/B
- Molecular classification
- Glycoprotein, Transmembrane protein, MHC class I-like molecule
01
Overview
MHC class I chain-related proteins A and B (MICA/B) are stress-induced cell surface glycoproteins that act as ligands for the activating immune receptor NKG2D, expressed on NK cells, γδ T cells, and CD8+ αβ T cells. They serve as "danger signals" on stressed or transformed cells, triggering immune responses. Shedding of MICA/B can lead to immune evasion, making them important targets for cancer immunotherapy.
- Other names
- MICAMICBMHC class I chain-related protein AMHC class I chain-related protein B
02
Mechanism of action
Block MICA/B shedding; enhance cell-surface retention of MICA/B to restore immune recognition.
03
Biological functions
Immune activationNKG2D ligand interactionTarget cell recognitionStress response
04
Disease associations
CancerImmune evasionInflammation
05
Safety considerations
NKG2D downregulationImmune evasion
06
Interacting drugs
Antibodies that block shedding
1 more in the full profile.
07
Biomarkers
Membrane-bound MICA/B levelsSoluble MICA/B levels
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