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Target intelligence / Profile preview
Human Leukocyte Antigen A*02 Complexed Peptide
- Molecular classification
- Cell-surface glycoprotein, MHC class I-peptide complex, Major Histocompatibility Complex
01
Overview
The Human leukocyte antigen A*02 complexed with a peptide forms an essential part of cellular immunity. It enables cytotoxic T-cell recognition of infected or transformed cells through presentation of intracellularly derived antigens. Its prevalence makes it especially important clinically—for transplantation matching—and scientifically—as an archetype target in immunology research and therapeutic development.
- Other names
- HLA-A*02-peptide complexHLA-A*02 complexMHC class I-peptide complex
02
Mechanism of action
Targeted by bispecific antibodies to redirect T-cells against cancer cells presenting specific peptide-HLA complexes.
03
Biological functions
Antigen presentationT cell activationImmune surveillanceSelf/non-self discrimination
04
Disease associations
Infectious diseasesAutoimmune disordersCancerTransplant rejection
05
Safety considerations
Potential for off-target effects in immunotherapiesRisk of cytokine release syndrome in T-cell redirection therapies
06
Biomarkers
Presence or absence of specific peptides presented by HLA-A*02
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