MHC class I polypeptide-related sequence E (MICE)

MHC class I polypeptide-related sequence E (MICE) is a mouse gene symbolically analogous to the human MICA and MICB genes, which encode major histocompatibility complex (MHC) class I-related proteins. In humans, MICA/B proteins are stress-induced ligands for NKG2D, an activating receptor on NK cells and certain T cells, and play an important role in immune surveillance, particularly in the context of infection or cellular stress. However, the specific gene "MHC class I polypeptide-related sequence E (MICE)" with the aliases dJ377H14.7 and PERB11.5, does not appear as a well-established or canonical protein target in mouse functional genomics or common immunology/therapeutics databases. There is evidence that in the mouse, genes named “Mice” (as opposed to “MICA”) do not have clear homologs with functional annotation equivalent to their human counterparts, and this name may reflect gene models or predictions rather than validated proteins. There are no drugs, disease roles, biological functions, or established biomarker use directly associated with "MICE" in the available mouse or human literature. Therefore, this does not represent a standard therapeutic target, and the entry is likely mischaracterized, misspelled, or refers to a non-canonical entity. If you intended to reference the human proteins MICA/MICB, these are established immune ligands. For the mouse, the functional orthologs and NKG2D ligands are encoded by other gene families (notably Rae-1, H60, and Mult-1). Note: If you require information about canonical NKG2D ligands in mouse, consider searching for “Rae-1,” “H60,” or “Mult-1” rather than “MICE."

Other names

dJ377H14.7PERB11.5MICE