Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MICAL-like protein 1 (MICALL1)
- Target
- MICALL1
- Molecular classification
- Other (Scaffold/adapter protein, endosomal trafficking effector), Rab effector protein
01
Overview
MICAL-like protein 1 (MICALL1) is a cytoplasmic scaffold protein involved in regulating tubular recycling endosome identity, membrane tubulation, and receptor/lipid recycling[1][2][3][4]. It binds phosphatidic acid and various small GTPases, notably Rab8a and Rab35, and recruits EHD1 and other proteins critical for assembling and regulating protein–lipid complexes on endosomal membranes[1][2][4]. MICALL1 is essential for the formation of tubular endosomes, endocytic recycling, and the trafficking of cell surface receptors, as well as for processes such as ciliogenesis, cytokinesis, and cell migration[1][2][3][4]. Diseases associated with MICALL1 include macular degeneration and Bardet-Bidl syndrome[3]. Currently, there are no known drugs that directly target MICALL1, nor is it classified as a conventional therapeutic target such as a receptor or enzyme[3].
- Other names
- MICAL-L1KIAA1668MIRAB13Molecule interacting with Rab13MICALL1
02
Biological functions
Regulation of plasma membrane tubulationProtein localization to endosomeEndocytic recycling (slow recycling pathway)Receptor trafficking (e.g., EGFR)Cargo protein delivery to plasma membraneCiliogenesis coordinationCell polarity, division, and migration
03
Disease associations
Macular degenerationBardet-BBSPotential roles in development and cell migration linked to disease processes[3]
Beyond the preview
Go deeper on MICAL-like protein 1 (MICALL1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MICAL-like protein 1 (MICALL1).