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Target intelligence / Profile preview
Microbiome-associated immune pathway
- Molecular classification
- Biological Pathway
01
Overview
The microbiome-associated immune pathway refers to the complex network of interactions between the host's immune system and its resident microbial communities, particularly those in the gut. This pathway encompasses both innate and adaptive immune responses that are shaped by, and in turn shape, the composition and activity of commensal microbes. The crosstalk is essential for maintaining immune homeostasis, protecting against pathogens, modulating inflammation, and supporting tissue integrity.
02
Mechanism of action
Modulation of the gut microbiota composition and activity, influencing host immune responses through MAMP-PRR interactions, microbial metabolites, and immune cell regulation.
03
Biological functions
Immune system developmentHomeostasisToleranceBarrier integrityInflammation controlDefense against pathogensModulation of the immune response
04
Disease associations
Inflammatory bowel diseaseAllergiesAutoimmune disordersIncreased infection susceptibilityDysbiosis-related diseases
05
Safety considerations
Risk of infection with FMTPotential for immune dysregulation with broad-spectrum immunomodulatory therapiesVariability in response to probiotics/prebiotics due to individual differences in microbiotaOff-target effects of drugs modulating host receptors
06
Interacting drugs
Probiotics
3 more in the full profile.
07
Biomarkers
Microbiota compositionLevels of microbial metabolites (SCFAs, bile acids, tryptophan derivatives)Expression of PRRs (TLRs)Levels of IgAFrequency of regulatory T cellsCytokine profiles (IL-10, TNF-α, IL-6)
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