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A microbiome modulator is a broad class of agents, interventions, or strategies designed to intentionally alter the structure and function of microbial communities, most commonly in the human gut, to achieve beneficial health outcomes. These modulators can be natural, induced, or engineered and may include dietary components, pharmaceuticals, probiotics/prebiotics/synbiotics, fecal microbiota transplantation (FMT), bacteriophages, nutraceuticals, and even immune-modulating therapies. They act via complex interactions between microbes and their human hosts at molecular levels involving both direct ecological shifts and indirect modulation through metabolite-receptor signaling pathways.
Varies depending on the specific modulator: - Direct alteration of microbial composition (probiotics, antibiotics). - Provision of selective substrates for beneficial microbes (prebiotics). - Transfer of entire microbial communities (FMT). - Modulation of host-microbe signaling pathways.
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