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Microbiome Modulators (None)
- Target
- None
- Molecular classification
- Biological Agents, Dietary Supplements, Pharmaceuticals
01
Overview
Microbiome modulators are agents or interventions designed to intentionally alter the structure and function of microbial communities, particularly those residing in the human body. These modulators aim to restore balance (eubiosis), correct dysbiosis (microbial imbalance), or enhance beneficial functions of the microbiota for improved health outcomes. Modulation involves shifting microbial composition, altering microbial metabolism, and modulating host-microbe interactions. Examples include probiotics, prebiotics, synbiotics, antibiotics, fecal microbiota transplantation (FMT), bacteriophages and dietary changes. Targets include bacterial taxa, metabolites like SCFAs, and host receptors such as PPARα/γ and GPR41/GPR43/GPR119.
- Other names
- ProbioticsPrebioticsSynbioticsAntibioticsFecal Microbiota Transplantation (FMT)BacteriophagesDietary Interventions
02
Mechanism of action
Shifting microbial composition, altering microbial metabolism, modulating host-microbe interactions
03
Biological functions
Microbiota modulationRestoration of eubiosisCorrection of dysbiosisImmune modulationMetabolic regulation
04
Disease associations
Gastrointestinal disordersInflammatory bowel diseaseIrritable bowel syndromeImmune-mediated diseasesMetabolic conditionsObesityDiabetesMental health disordersInfectionsClostridium difficile infection
05
Safety considerations
Off-target effectsAntibiotic resistanceLack of standardizationVariable efficacyPotential for adverse immune responsesLong-term effects unknown
06
Interacting drugs
Antibiotics
1 more in the full profile.
07
Biomarkers
Specific bacterial taxaShort-chain fatty acids (SCFAs)Bile acidsTrimethylamine N‑oxide
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