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Microbiota-Gut-Brain Axis (MGB Axis)

Target: MGB Axis
Molecular classification: Biological System, Communication Network

Overview

The microbiota-gut-brain axis is a complex, bidirectional communication network linking the gut microbiota, the gastrointestinal tract, and the central nervous system. It integrates neural, hormonal, immune, and metabolic signaling pathways to regulate both gut and brain functions. Disruptions in this communication network (dysbiosis) have been associated with a range of functional gastrointestinal disorders as well as psychiatric illnesses.

Other names: Gut-Brain AxisMicrobiome-Gut-Brain Axis

Mechanism of action

Modulation of gut microbiota composition and function to influence brain activity via neural, endocrine, immune, and metabolic pathways.

Biological functions

Bidirectional signaling between the gut and brainRegulation of digestive healthModulation of mental well-beingRegulation of behaviorRegulation of moodRegulation of cognitionImmune response modulationHomeostasis maintenance

Disease associations

Functional gastrointestinal disorders (e.g., IBS)Psychiatric illnesses (e.g., depression, anxiety)Neurodevelopmental conditions (e.g., autism spectrum disorder)Neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease)Motility disorders

Safety considerations

Potential for unintended consequences of microbiota manipulationLong-term effects of FMT are not fully understoodVariability in individual responses to dietary interventions

Interacting drugs

Probiotics

3 more in the full profile.

Biomarkers

Microbiome signaturesShort-chain fatty acids (SCFAs)Bile acidsAmino acids

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