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Microcin (Mcc)
- Target
- Mcc
- Molecular classification
- Antimicrobial Peptide, Ribosomally synthesized peptide, Enzyme Inhibitor (various), Pore-forming peptide
01
Overview
Microcins are a class of low-molecular-weight, ribosomally synthesized antimicrobial peptides produced by certain Gram-negative bacteria. They exhibit potent antibacterial activity against closely related bacterial species through diverse mechanisms like membrane disruption, enzyme inhibition, and ROS generation. They are being explored as novel antimicrobials and microbiome modulators due to their stability and activity against antibiotic-resistant pathogens.
- Other names
- MicrocinsMccB17MccCMccJ25MccH47MccVMccE492Kp G492
02
Mechanism of action
Variable, including: - Membrane pore formation - Aspartyl-tRNA synthetase inhibition - DNA gyrase inhibition - RNA polymerase inhibition - Disruption of cellular respiration - Reactive oxygen species generation
03
Biological functions
Antibacterial activityInterbacterial competitionMicrobiome modulationEnzyme inhibitionMembrane disruptionReactive oxygen species generation
04
Disease associations
InfectionGut dysbiosis
05
Safety considerations
Potential for off-target effectsPotential for immunogenicity
06
Interacting drugs
Colistin (synergistic)
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