Microfibril-associated protein 1 (MFAP1)

Microfibril-associated protein 1 (MFAP1) is a spliceosome-associated protein involved in nuclear pre-mRNA splicing as part of the U2-type precatalytic spliceosome complex[2][7]. While originally named for its association with microfibrils in the extracellular matrix, subsequent studies have established its primary intracellular function as a scaffold facilitating the assembly and regulation of the spliceosome, aiding in alternative and constitutive splicing regulation[2][5][7]. It interacts directly with the Prp38 protein complex and contains highly conserved motifs involved in protein-protein interactions within the spliceosome[2][6]. MFAP1 expression is widespread across tissues and is considered essential for efficient mRNA splicing, but is not itself a therapeutic target such as a receptor, enzyme, or transporter[2][7]. Disease relevance is suggested by associations with conditions including juvenile glaucoma, but no direct involvement with drugs or known clinical biomarkers is reported[7].

Other names

Microfibrillar-associated protein 1AMPSpliceosome B complex protein MFAP1AMP, MFAP1, spliceosome B complex protein MFAP1