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Target intelligence / Profile preview
Micropeptide inhibiting actin cytoskeleton (MIAC)
- Target
- MIAC
- Molecular classification
- Other (micropeptide, lncRNA-derived peptide), Non-coding RNA (AQP5-AS1 transcript)
01
Overview
Micropeptide inhibiting actin cytoskeleton (MIAC) is a 51-amino acid micropeptide encoded by the lncRNA AQP5-AS1 (also called AC025154.2). Recent research has shown that MIAC is endogenously expressed in humans and acts as a tumor suppressor by regulating the actin cytoskeleton, mainly through direct interaction with Aquaporin 2 (AQP2). This leads to inhibition of tumor growth and metastasis, especially in head and neck squamous cell carcinoma. Low expression of MIAC is associated with worse survival outcomes in cancer patients. MIAC also modulates signaling via SEPT2 and ITGB4 and can influence EGFR pathway activity, further impacting cancer progression.
- Other names
- AQP5 and AQP2 antisense RNA 2AQP5-AS1AC025154.2MIACmicropeptide inhibiting actin cytoskeleton
02
Mechanism of action
Direct interaction with Aquaporin 2 (AQP2) to modulate cytoskeletal signaling via SEPT2/ITGB4 pathways
03
Biological functions
Actin cytoskeleton regulationTumor suppressionInhibition of cell migration and metastasis
04
Disease associations
Cancer (especially head and neck squamous cell carcinoma, HNSCC)
05
Biomarkers
MIAC expression levels (prognostic marker for HNSCC survival)
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