MicroRNA-1 seed-matched messenger RNA transcripts (miR-1 target mRNAs)

MicroRNA-1 (miR-1) seed-matched mRNA transcripts represent the collection of messenger RNAs regulated by miR-1, a highly conserved, muscle-specific microRNA known as a myomiR (Zhao et al., 2005, Nature). These transcripts are identified by the presence of sequences complementary to the miR-1 seed region (nucleotides 2-8) within their 3' untranslated regions (UTRs), which allows the miR-1-induced silencing complex (miRISC) to mediate gene silencing (Bartel, 2009, Cell). miR-1 plays a pivotal role in cardiac and skeletal muscle development by targeting transcripts such as GJA1 (Connexin 43) and KCNJ2 (Kir2.1), which are essential for maintaining normal cardiac rhythm and electrical conduction (Yang et al., 2007, Nature Medicine). Additionally, miR-1 regulates myogenic differentiation by targeting transcription factors and signaling molecules like HDAC4 and PAX7 (Chen et al., 2006, Nature Genetics). In pathological contexts, the dysregulation of these seed-matched transcripts is associated with cardiac hypertrophy, myocardial infarction, and various cancers where miR-1 often functions as a tumor suppressor by targeting oncogenic mRNAs like MET and E2F3 (Nasser et al., 2008, JBC). Therapeutic strategies targeting this network involve the use of miR-1 mimics to restore regulation of these transcripts in disease states or antagomirs to de-repress specific targets, though such approaches must carefully manage the risk of inducing arrhythmias or off-target effects (van Rooij & Kauppinen, 2014, EMBO Mol Med).

Other names

miR-1 targetsMicroRNA-1 regulated mRNAshsa-miR-1-3p targetsmiR-1-3p seed-matched transcripts

MicroRNA-mediated post-transcriptional gene silencing via mRNA degradation or translational inhibition.