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MicroRNA-101 (miR-101)
- Target
- miR-101
- Molecular classification
- Non-coding RNA, MicroRNA
01
Overview
MicroRNA-101 (miR-101) is a small non-coding RNA that functions as a tumor suppressor by regulating key oncogenes and participating in processes like cell proliferation, apoptosis, and tumor invasion. It is often downregulated in various cancers and has been implicated in fibrosis and cardiovascular diseases as well[1][3].
- Other names
- miR-101-1miR-101-2miR-101-3pmiR-101-5p
02
Mechanism of action
Primarily through post-transcriptional regulation of gene expression by binding to the 3' untranslated region (3'UTR) of target mRNAs, leading to mRNA degradation or translational inhibition. Targets include oncogenes like EZH2, MCL-1, and FOS[1][2].
03
Biological functions
Signal transductionCell proliferationApoptosisCell migrationCell invasionCell senescence
04
Disease associations
CancerFibrosisCardiovascular disease
05
Safety considerations
The therapeutic use of miR-101 could face challenges related to delivery and specificity, as altering microRNA levels can have widespread effects on gene expression[3].
06
Interacting drugs
paclitaxel
07
Biomarkers
miR-101 itself is considered a potential biomarker for various cancers, reflecting its role as a tumor suppressor[1][3].
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