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Target intelligence / Profile preview
MicroRNA 103 (miR-103)
- Target
- miR-103
- Molecular classification
- Non-coding RNA, microRNA
01
Overview
MicroRNA 103 (miR-103) is a short, non-coding RNA molecule that regulates gene expression by binding to the 3'UTRs of target mRNAs, resulting in translational repression or mRNA degradation. It is involved in various cellular processes including cell cycle, cell death, metabolism, and EMT. It is closely related to miR-107 and shares significant sequence homology and functional overlap.
- Other names
- hsa-miR-103miR-103a
02
Mechanism of action
Binds to the 3' untranslated regions (3'UTRs) of target mRNAs, leading to translational repression or mRNA degradation.
03
Biological functions
Post-transcriptional gene silencingRegulation of gene expressionCell cycle regulationRegulation of cell deathRegulation of cellular growth and proliferationRegulation of insulin sensitivity and glucose metabolismRegulation of epithelial-mesenchymal transition (EMT)
04
Disease associations
ObesityType 2 diabetesCancer metastasisCardiovascular diseaseMyocardial infarctionOxidative stress
05
Safety considerations
Off-target effects due to broad regulatory scopePotential for dysregulation of multiple pathways
06
Biomarkers
miR-103 expression levels in obesitymiR-103 expression levels in cancer cells
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