MicroRNA 103a-2 (MIR103A2)

MicroRNA 103a-2 is a member of the miR-103 gene family and encodes a non-coding RNA molecule involved in post-transcriptional regulation of gene expression, typically by binding to complementary sequences in target mRNAs and inhibiting their stability or translation[2][6]. MIR103A2 is upregulated in several cancer types, where its expression is associated with cell proliferation, migration, invasion, enhanced glucose metabolism, and poor prognosis[1][4]. It also regulates vascular calcification by targeting specific transcription factors such as RUNX2[5]. Experimental strategies to modify its function include miRNA mimics and inhibitors, and its circulating levels show promise as non-invasive biomarkers for disease diagnosis and prognosis[7].

Other names

hsa-mir-103-2hsa-mir-103a-2MIR103-2MIRN103-2mir-103a-2microRNA 103-2MIR103A2

miRNA mimics: increase MIR103A2 function to downregulate target mRNAs miRNA inhibitors (antagomirs): block MIR103A2 function, derepressing target genes[6] Regulation via nuclear receptor RXRα, which binds pre-miR-103a-2 to affect maturation and abundance[3]