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MicroRNA 107 (None)
- Target
- None
- Molecular classification
- Non-coding RNA, microRNA
01
Overview
MicroRNA 107 (miR-107) is a small, non-coding RNA molecule belonging to the microRNA family. It plays a significant role in post-transcriptional regulation of gene expression by binding to target mRNAs, leading to their degradation or translational repression. It regulates multiple cellular pathways, including cell proliferation, angiogenesis and lipid metabolism. miR-107 is implicated in diseases such as Alzheimer's and various cancers where it can have context-dependent roles.
- Other names
- miR-107MIR107
02
Mechanism of action
miR-107 binds primarily to the 3′ untranslated regions (UTRs) of target mRNAs through imperfect base pairing, leading either to inhibition of translation initiation/elongation or direct mRNA degradation.
03
Biological functions
Regulation of gene expressionCell proliferationAngiogenesisLipid metabolismRegulation of translationRegulation of mRNA degradation
04
Disease associations
Alzheimer's DiseaseCancerColorectal CancerHead & Neck CarcinomaLung CancerOsteoarthritis
05
Safety considerations
Potential off-target effects due to broad target range of microRNAsContext-dependent role in cancer (tumor suppressor vs. oncogene)
06
Biomarkers
miR-107 expression levels in Alzheimer's DiseasemiR-107 expression levels in Colorectal CancermiR-107 expression levels in Head & Neck CarcinomamiR-107 expression levels in Lung Cancer
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