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Target intelligence / Profile preview
MicroRNA 10b (miR-10b)
- Target
- miR-10b
- Molecular classification
- MicroRNA, Non-coding RNA
01
Overview
MicroRNA 10b (miR-10b) is a small non-coding RNA molecule involved in post-transcriptional regulation of gene expression. It plays a significant role in cancer biology, particularly in promoting metastasis and maintaining cancer stem cell properties. miR-10b functions by binding to the 3' untranslated regions (UTRs) of target mRNAs, leading to their degradation or translational repression. It is overexpressed in metastatic lesions and promotes cell migration and invasion by targeting key regulators such as HOXD10. Inhibition of miR-10b is being explored as a therapeutic strategy for aggressive and refractory cancers.
- Other names
- MIR10B
02
Mechanism of action
Binds to 3' UTR of target mRNAs leading to degradation or translational repression.
03
Biological functions
Post-transcriptional gene regulationRegulation of metastasisMaintenance of cancer stem cell phenotypeRegulation of cell migration and invasionmRNA degradationTranslational repression
04
Disease associations
CancerMetastasisBreast CancerGastric Cancer
05
Safety considerations
Off-target effects of miRNA inhibitorsPotential for affecting normal miRNA function
06
Interacting drugs
MN-anti-miR-10b nanodrugs
07
Biomarkers
miR-10b expression levels in tumors and metastatic lesions
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