MicroRNA 10b-5p target messenger RNAs (miR-10b-5p targets)

MicroRNA 10b-5p (miR-10b-5p) target messenger RNAs (mRNAs) represent a diverse group of transcripts that are post-transcriptionally regulated by the oncogenic microRNA miR-10b-5p (Ma et al., Nature, 2007). This microRNA is frequently upregulated in metastatic cancers, particularly breast cancer and glioblastoma, where it acts as a key driver of the metastatic cascade (Sun et al., Mol Cancer, 2015). The primary mechanism involves miR-10b-5p binding to the 3' untranslated regions (UTRs) of target mRNAs, such as Homeobox D10 (HOXD10), leading to their degradation or translational inhibition. The resulting loss of HOXD10 expression triggers the upregulation of pro-metastatic genes like RHOC, which enhances cell migration and invasion (Ma et al., Nature, 2007). Other validated targets include Kruppel-like factor 4 (KLF4) and TP53, which influence cell proliferation and survival (Liu et al., 2016). Therapeutic intervention typically utilizes antisense oligonucleotides, such as TTX-MC138, to sequester miR-10b-5p and restore the expression of these tumor-suppressive target mRNAs (TransCode Therapeutics, 2023). Consequently, these target mRNAs serve as the functional effectors of miR-10b-5p's oncogenic activity and are critical focal points for understanding RNA-based gene regulation in disease.

Other names

miR-10b targetshsa-miR-10b-5p regulated genesMicroRNA 10b-5p regulated transcriptsmiR-10b-5p targetome

Antisense oligonucleotides or antagomirs bind to miR-10b-5p with high affinity, preventing it from interacting with the 3' untranslated regions (UTRs) of its target mRNAs, thereby preventing mRNA degradation and restoring protein translation of tumor suppressors like HOXD10.