MicroRNA 1182 (miR-1182)

MicroRNA 1182 is a small, non-coding RNA (20-24 nucleotides) classified as a microRNA (miRNA) involved in post-transcriptional regulation of gene expression[1]. It functions by binding target mRNAs, typically resulting in translational inhibition or mRNA destabilization through the RNA-induced silencing complex (RISC)[1]. MicroRNA 1182 has been identified as a tumor suppressor in cholangiocarcinoma, where it synergizes with let-7a to inhibit cancer cell invasion, migration, autophagy, and tumor progression by targeting and suppressing NUAK1[3]. Like other miRNAs, MIR1182 is implicated in regulating a range of cellular processes including cell proliferation, differentiation, and apoptosis, and has potential as both a disease biomarker and a therapeutic target, particularly in oncology[1][3][6].

Other names

hsa-mir-1182MIRN1182MIR1182

Down-regulation of target gene expression (e.g., NUAK1 in cholangiocarcinoma) via sequence-specific binding to mRNA. Inhibition of cell proliferation, invasion, and migration by targeting specific mRNAs.