MicroRNA 1184-1 (MIR1184-1)

MicroRNA 1184-1 (MIR1184-1, hsa-mir-1184-1) is a small, non-coding RNA molecule classified as a microRNA that is involved in regulating gene expression at the post-transcriptional level[2][4]. It is processed from a stem-loop precursor transcript and functions primarily by base pairing with specific target mRNAs to promote their degradation or inhibit their translation[2]. MIR1184-1 has been implicated in the regulation of cell proliferation and apoptosis, with roles in various diseases such as cancer, inflammation, and degenerative conditions[4][5]. Mechanistically, it is known to interact with and modulate important signaling pathways such as PI3K/AKT and RAS, and may regulate the expression of cancer-related genes (e.g., CSNK2A1, HRAS/KRAS/NRAS)[4][5][6]. Its altered expression has been observed in multiple cancers and inflammatory diseases, making it a potential biomarker and possible, though indirect, therapeutic target[4][5][6]. No drugs are currently known to selectively modulate MIR1184-1 activity, but its role as a regulatory RNA places it at the intersection of key gene-regulatory and disease-associated networks.

Other names

hsa-mir-1184-1MIR1184MIRN1184microRNA 1184hsa-mir-1184

No direct drugs described; activity is based on base pairing with target mRNAs leading to mRNA degradation or inhibition of translation