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microRNA 1185-1 (miR-1185-1)
- Target
- miR-1185-1
- Molecular classification
- microRNA, Non-coding RNA, Other (specifically, an endogenous small RNA gene regulator)
01
Overview
microRNA 1185-1 is a human non-coding RNA that belongs to the microRNA family, which serve as endogenous post-transcriptional regulators of gene expression. It is annotated as hsa-miR-1185-1 in miRBase and scientific databases[2][3]. Recent evidence suggests that miR-1185-1 may act as a tumor suppressor in cancer: its downregulation is associated with increased stemness features in colorectal cancer cells, and its expression forms part of a miRNA signature capable of discriminating between early-stage and advanced-stage breast cancer[2][3]. However, its precise molecular targets, mechanisms of biological action, and potential for therapeutic modulation remain largely undefined in the current literature.
- Other names
- hsa-mir-1185-1MIRN1185-1mir-1185-1hsa-miR-1185-1miR-1185-1
02
Biological functions
Negative regulation of gene expression (post-transcriptional silencing)Putative tumor suppressor functionOther (details lacking about direct functional targets and pathways)
03
Disease associations
Cancer (breast and colorectal cancer: altered expression correlates with disease attributes; breast cancer stage classification; colorectal cancer stemness control)Other (not enough evidence for inclusion in neurodegenerative, cardiovascular, or infection)
04
Safety considerations
no direct therapeutic interventions on miR-1185-1 reported; standard safety concerns for RNA therapies may apply if developed
05
Biomarkers
Cancer stage prediction (miR-1185-1 is part of a multimiRNA signature for distinguishing early versus advanced breast cancer)Tumor suppressor status (downregulation linked to cancer stemness in colorectal cancer)
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