microRNA 1199 (miR-1199-5p)

microRNA 1199 (miR-1199-5p) is a small non-coding RNA molecule involved in post-transcriptional regulation of gene expression, primarily acting by binding to complementary sequences on target mRNAs and leading to their degradation or translational repression[3][1]. miR-1199-5p has a key role in regulating the epithelial–mesenchymal transition (EMT), a process central to tumor metastasis and cancer cell invasion[1]. It is notably downregulated during EMT and in mesenchymal-like cancer cells, while its overexpression inhibits EMT, suppresses cancer cell migration and invasion, and sustains the epithelial phenotype[1][3]. Mechanistically, miR-1199-5p operates in a double-negative feedback loop with the transcription factor ZEB1—a central EMT regulator—similar to but distinct from the miR-200 family, regulating EMT plasticity and metastatic potential[1]. In addition, miR-1199-5p can directly target the mRNA of 5α-reductase type 2 (SRD5A2), inhibiting its expression and imparting regulatory effects relevant to prostate biology[3]. Its expression profile and regulatory effects make it a candidate biomarker for tumor aggressiveness and epithelial status as well as a potential therapeutic target in oncology research.

Other names

hsa-mir-1199hsa-mir-1199-5pmiR-1199-5pmicroRNA mir-1199

Gene silencing through mRNA targeting, Suppression of transcription factor ZEB1 expression, Direct inhibition of SRD5A2 mRNA