MicroRNA 1204 (miR-1204)

MicroRNA 1204 (miR-1204) is a short non-coding RNA molecule found in the human genome within the PVT1 region at chromosome 8q24. It is involved in post-transcriptional regulation of gene expression by guiding the RNA-induced silencing complex (RISC) to specific messenger RNAs, resulting in their translational repression or degradation[3]. miR-1204 is overexpressed in several types of cancer, including breast, ovarian, and non-small-cell lung cancer, where it promotes cell proliferation, reduces cell cycle arrest, and inhibits tumor suppressor gene expression such as PITX1[1][2][4]. Inhibition of miR-1204 using antisense oligonucleotides can reduce tumor growth and induce apoptosis in PVT1-amplified cancers[2]. Elevated miR-1204 levels are associated with poor prognosis and more aggressive disease phenotypes, making it both a biomarker and a potential therapeutic target in oncology[1][2][4].

Other names

MIR1204hsa-mir-1204hsa-miR-1204microRNA-1204

Antisense oligonucleotides (antagomirs) inhibit miR-1204 activity, leading to reduced cell proliferation and increased apoptosis in cancer cells[2].