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Target intelligence / Profile preview
microRNA-122 (miR-122)
- Target
- miR-122
- Molecular classification
- microRNA, Non-coding RNA
01
Overview
microRNA-122 (miR-122) is a highly conserved, liver-specific microRNA that plays critical roles in hepatic biology, disease, and metabolism. It is one of the most abundant miRNAs in the liver, constituting up to 70% of total hepatic miRNAs. It functions primarily through binding to complementary sequences within the 3′ untranslated regions (UTRs) of target mRNAs via its seed sequence, leading to mRNA degradation or translational repression.
- Other names
- hsa-miR-122MIR122
02
Mechanism of action
Binds to the 3' UTR of target mRNAs, leading to mRNA degradation or translational repression.
03
Biological functions
Regulation of cholesterol/fatty acid metabolismModulation of innate immunityTumor suppressionRegulation of gene expressionPost-transcriptional regulation
04
Disease associations
Hepatocellular carcinomaBile duct cancerHepatitis C virus infectionMetabolic disordersLiver injury
05
Safety considerations
Potential off-target effects of anti-miR therapiesContext-dependent dual roles in cancer
06
Interacting drugs
Antisense oligonucleotides targeting miR-122
1 more in the full profile.
07
Biomarkers
Elevated serum/plasma levels correlate with hepatocyte damageBiomarker for liver injury/cancer/viral hepatitisHepatitis C virus infection/disease progression
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