microRNA-1224 (miR-1224)

MicroRNA-1224 (miR-1224) is an endogenous non-coding RNA, approximately 20–22 nucleotides in length, primarily functioning in the negative post-transcriptional regulation of gene expression by binding to the 3’ untranslated regions (3’UTRs) of target mRNAs[1][2]. It is located on human chromosome 3q27.1, originating from the last intron of the VWA5B2 gene, and is considered a “mirtron” (a microRNA processed from an intron without Drosha cleavage)[1]. miR-1224 has two mature forms: miR-1224-5p and miR-1224-3p, each participating in distinct regulatory roles. Extensive research supports its function as a tumor suppressor in diverse cancers (lung, gastric, glioma, osteosarcoma, bladder, colorectal, hepatocellular carcinoma, melanoma, and others); it inhibits cell proliferation, migration, invasion, promotes apoptosis and autophagy, and regulates key oncogenic pathways such as Wnt/β-catenin and EMT. Additionally, miR-1224 is implicated in other diseases, including acute liver failure and neurodegeneration. Its aberrant expression is associated with cancer development and prognosis, positioning it as a potential biomarker and therapeutic target[1][2]. Notes: - There are currently no approved drugs that directly modulate miR-1224; its role is as a biomarker and potential experimental target, but no drugs in clinical practice target this microRNA specifically[1][2]. - It is not a protein or classical drug receptor, enzyme, transporter, or ion channel, but a regulatory non-coding RNA; classification is best as "other" under molecular classifications[1][2]. - There are no known canonical safety liabilities specific to miR-1224, but gene therapy or oligonucleotide therapeutics targeting microRNA(s) in general should be approached cautiously due to the broad impact on gene networks.

Other names

hsa-miR-1224MIRN1224miR-1224hsa-mir-1224MIR1224

Gene silencing via binding to the 3’ untranslated region (3’UTR) of mRNA, leading to mRNA degradation or translational repression