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Target intelligence / Profile preview
MicroRNA 1228 (miR-1228)
- Target
- miR-1228
- Molecular classification
- MicroRNA, non-coding RNA, small RNA, Other
01
Overview
MicroRNA 1228 (miR-1228, also known as hsa-mir-1228) is a member of the microRNA family, a class of short (20–24 nucleotide) non-coding RNAs involved in the post-transcriptional regulation of gene expression by destabilizing target mRNAs or repressing their translation. It is transcribed as an RNA stem-loop and processed to a mature miRNA incorporated into the RNA-induced silencing complex (RISC). MiR-1228 is widely recognized as a highly stable and reliable endogenous control for the normalization of circulating microRNA measurements in human plasma and serum, especially in the context of cancer biomarker studies. It does not appear to be a direct drug target or receptor, but plays housekeeping-like roles in gene expression regulation and is used as a technical reference in diagnostics.
- Other names
- hsa-mir-1228MIR1228MIRN1228mir-1228miR-1228-3p
02
Biological functions
Post-transcriptional regulation of gene expressionModulation of mRNA stability and translationInvolvement in cell morphologyCell death and survivalHematological system developmentMetabolism-related signal pathways
03
Disease associations
Cancer (notably as a stable reference miRNA in studies of colorectal, lung, hepatocellular, breast, renal, prostate, gastric, and esophageal cancers)Endometrial adenocarcinomaPleural cancer
04
Safety considerations
No safety concerns reported; mainly used as a normalization standard, not a therapeutic target
05
Biomarkers
Used as a stable endogenous control (reference gene) for quantification of circulating microRNAs in plasma and serum, especially in cancer liquid biopsy research
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