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MicroRNA-124 (miR-124)
- Target
- miR-124
- Molecular classification
- Small non-coding RNA, microRNA
01
Overview
MicroRNA-124 (miR-124) is a small non-coding RNA molecule that regulates gene expression at the post-transcriptional level. It is highly expressed in the central nervous system and immune cells, playing critical roles in neuronal differentiation, immune modulation, and tumor suppression. It functions by binding to target mRNAs, leading to their degradation or translational repression. miR-124 has potential as a therapeutic target and biomarker for various diseases, particularly cancer and neurological disorders.
- Other names
- MicroRNA 124hsa-miR-124
02
Mechanism of action
Post-transcriptional regulation via RISC binding to mRNA, leading to mRNA degradation or translational repression.
03
Biological functions
Regulation of gene expressionNeuronal differentiationCell proliferationNeurogenesisImmune modulationTumor suppressionAutophagy regulationInflammation regulation
04
Disease associations
CancerNeurological disordersImmune dysfunctionsPulmonary hypertension
05
Safety considerations
Off-target effects due to broad regulatory roleContext-dependent effects (can be tumor suppressor or promoter)Delivery challenges for therapeutic applications
06
Biomarkers
Diagnostic biomarker for cancerPrognostic biomarker for cancer
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