MicroRNA 1252 (miR-1252 (also seen as miR-1252-5p when referring to mature strand))

MicroRNA 1252 is a small, non-coding RNA (approximately 22 nucleotides) involved in post-transcriptional gene silencing via binding to target mRNAs, leading to their degradation or translational repression[5]. In humans, it is encoded at chromosome 12q21.2 and is mainly studied in its mature form, miR-1252-5p. It has been found to act as a tumor suppressor in pancreatic adenocarcinoma by inhibiting cell migration, invasion, proliferation, and epithelial-mesenchymal transition—largely through direct targeting and downregulation of genes such as NEDD9 and HPSE[1][3]. In multiple myeloma, higher miR-1252-5p levels sensitize cells to the chemotherapeutic agent bortezomib by repressing heparanase (HPSE) expression. The molecule participates in various cancer-related pathways and is part of the broader family of microRNAs, which are deeply involved in fine-tuning gene networks through Argonaute protein-mediated mechanisms[4][5]. There are currently no approved drugs that directly target microRNA 1252 for therapeutic purposes, but synthetic mimics or inhibitors are under investigation for their potential in cancer therapy[3].

Other names

hsa-miR-1252hsa-mir-1252MIR1252MIRN1252microRNA-1252-5pmiR-1252-5p

Functions as a gene silencer by binding to complementary sequences in target mRNAs, leading to mRNA degradation or inhibition of translation. Sensitizes cells to bortezomib by downregulating expression of heparanase (HPSE).