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Target intelligence / Profile preview
MicroRNA 1253 (hsa-miR-1253)
- Target
- hsa-miR-1253
- Molecular classification
- MicroRNA, Non-coding RNA
01
Overview
MicroRNA 1253 (hsa-miR-1253) is a small, noncoding RNA molecule expressed in Homo sapiens, functioning primarily in the post-transcriptional regulation of gene expression. It acts as a tumor suppressor in several cancer types by targeting oncogenic factors such as WNT5A, CDK6, and CD276, thereby inhibiting cell proliferation, invasion, promoting apoptosis, and cell cycle arrest[4][6]. Decreased expression of hsa-miR-1253 has been associated with increased malignancy in cancers like non-small cell lung carcinoma, medulloblastoma, and breast cancer[1][2][4][6].
- Other names
- hsa-miR-1253MIR1253
02
Mechanism of action
Suppression of gene targets (e.g., WNT5A, CDK6, CD276) leading to reduced proliferation, invasion, promotion of apoptosis, and cell cycle arrest
03
Biological functions
Regulation of gene expression (post-transcriptional)Suppression of cell proliferation and invasionActivation of apoptotic pathwaysCell cycle arrest
04
Disease associations
Cancer (e.g., non-small cell lung carcinoma, medulloblastoma, breast cancer)
05
Safety considerations
No specific safety concerns found, though manipulating microRNA levels in therapy could have off-target regulatory effects.
06
Interacting drugs
None reported in current search results; microRNAs themselves are not direct drug targets but may be affected by experimental therapeutics or RNA-based drugs
07
Biomarkers
Downregulation or altered expression of hsa-miR-1253 in various cancers (e.g., male breast cancer, medulloblastoma) is observed, which may have biomarker potential for cancer diagnosis or prognosis
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