MicroRNA 1255b-1 (MIR1255B1)

MicroRNA 1255b-1 is a member of the miR-125 family, encoded by the MIR1255B1 gene and classified as a non-coding microRNA involved in regulatory functions at the post-transcriptional level[1][2]. Like other miR-125 family members, MIR1255B1 acts by incorporating into the RNA-induced silencing complex (RISC) to inhibit or destabilize target mRNAs through imperfect base pairing, thereby influencing processes such as cell differentiation, proliferation, apoptosis, and immune responses[1][3]. The miR-125 family, which includes MIR1255B1, has been implicated in both tumor suppressive and tumor promoting roles depending on disease context, particularly in various carcinomas and hematologic cancers such as B-cell acute lymphoblastic leukemia and acute myeloid leukemia[3]. While members of the miR-125 family are being explored as therapeutic targets and disease biomarkers, MIR1255B1 itself is primarily studied for its biological functions and disease associations rather than as a direct drug target[1][3][6].

Other names

hsa-mir-1255b-1MIRN1255B1MIR1255B-1