MicroRNA 125b-3p regulated messenger RNAs (miR-125b-3p targets)

MicroRNA 125b-3p (formerly known as miR-125b*) regulated messenger RNAs (mRNAs) represent a diverse set of transcripts controlled by the miR-125b-3p guide strand (miRBase). This microRNA is part of the miR-125 family, which is highly conserved and plays critical roles in developmental timing, cell differentiation, and homeostasis (PubMed: 21102438). By binding to the 3' untranslated regions of specific mRNAs, miR-125b-3p typically induces translational repression or transcript degradation, thereby downregulating the expression of proteins such as BAK1 and PRDM1 (PubMed: 23536559). In various pathological contexts, particularly oncology, the dysregulation of these target mRNAs contributes to tumor progression, chemoresistance, and altered immune responses (PubMed: 25605237). Therapeutic strategies often involve the use of synthetic miRNA mimics to restore regulation or antagomirs to block the miRNA's inhibitory effect on its target mRNAs (PubMed: 23913112). However, the broad spectrum of mRNAs regulated by a single microRNA poses significant challenges for therapeutic specificity and safety. Understanding the specific mRNA targets of miR-125b-3p is essential for developing precision medicine approaches that can modulate specific pathways without widespread off-target effects.

Other names

miR-125b* targetsmiR-125b-3p targetsMicroRNA 125b-3p regulated geneshsa-miR-125b-3p targets

MicroRNAs regulate their target mRNAs through sequence-specific binding to the 3' untranslated region (UTR), leading to translational inhibition or mRNA degradation (PubMed: 21102438).