MicroRNA-126-3p targets (miR-126-3p targets)

MicroRNA-126-3p targets refers to the collection of messenger RNAs regulated by the microRNA miR-126-3p, which is predominantly expressed in endothelial cells and plays a vital role in vascular homeostasis (Fish et al., 2008, Science). miR-126-3p functions by binding to the 3' untranslated regions (UTRs) of target mRNAs, leading to their degradation or the inhibition of their translation (Wang et al., 2008, Developmental Cell). Key targets include SPRED1 and PIK3R2, which modulate the VEGF and MAPK signaling pathways to control angiogenesis and cell survival (Zampetaki et al., 2010, Circulation Research). In the context of disease, miR-126-3p is often downregulated in conditions like diabetes and certain cancers, resulting in the overexpression of its mRNA targets and subsequent pathological signaling (Witkowski et al., 2016, Arteriosclerosis, Thrombosis, and Vascular Biology). Because a single miRNA can regulate hundreds of different mRNAs, these targets represent a complex regulatory network rather than a single therapeutic entity (Santulli, 2015, Journal of Clinical Investigation). Therapeutic interventions targeting this axis typically utilize miRNA mimics to restore normal regulation across this broad set of genes.

Other names

miR-126-3p targetsmicroRNA-126-3p regulated mRNAsAdditional miR-126-3p mRNA targets

Post-transcriptional gene silencing