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Target intelligence / Profile preview
MicroRNA 1262 (miR-1262)
- Target
- miR-1262
- Molecular classification
- microRNA (miRNA), Non-coding RNA
01
Overview
MicroRNA 1262 (miR-1262) is a short (typically 20–24 nucleotides) non-coding RNA molecule transcribed by RNA polymerase II. It functions as part of the microRNA machinery, regulating gene expression by degrading target mRNA or inhibiting their translation following binding through imperfect base pairing. The mature miR-1262 is produced from a stem-loop precursor and incorporated into the RNA-induced silencing complex (RISC), controlling mRNA targets. Diseases associated with genetic loci of miR-1262 include cardia cancer and gastric cardia adenocarcinoma, but its specific role and regulatory network are still being elucidated. No direct therapeutic drugs, biomarkers, or safety profiles are established for miR-1262 at this time.
- Other names
- hsa-mir-1262MIRN1262MIR1262mir-1262
02
Biological functions
Gene expression regulation (post-transcriptional repression via mRNA destabilization and translational inhibition)Cell differentiationApoptosis (general miRNA roles; specific role for miR-1262 is under investigation)Other (dependent on tissue-specific expression and disease context)
03
Disease associations
Cancer (specifically cardia cancer and gastric cardia adenocarcinoma; based on genetic association)Other (potential roles in immune regulation or other conditions are not well-defined for miR-1262)
04
Safety considerations
Therapeutic targeting miRNAs in general can have off-target effects due to wide mRNA regulatory networks and tissue-specific expression, but no specific safety profile for miR-1262 is reported.
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