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MicroRNA 1263 (miR-1263)
- Target
- miR-1263
- Molecular classification
- microRNA, non-coding RNA
01
Overview
MicroRNA 1263 is a short (20–24 nucleotide) non-coding RNA molecule, part of a class of microRNAs that regulate gene expression mainly by destabilizing or inhibiting translation of target mRNAs[2]. It is transcribed from the human genome as part of a longer precursor molecule, which is processed by Drosha and Dicer enzymes to yield the mature form[2]. miR-1263 has been identified as highly enriched in definitive endoderm cells during differentiation of human embryonic stem cells and is a critical regulator promoting endoderm cell fate through repression of key pluripotency factors such as KLF4[1]. Its role in disease is not currently defined, and it is not known to be directly targeted by therapeutic agents or used as a clinical biomarker.
- Other names
- hsa-mir-1263MIR1263MIRN1263
02
Biological functions
Regulation of gene expressionPromotion of endoderm differentiation in human embryonic stem cells (hESCs)Repression of pluripotency regulators (e.g., KLF4)Cell-fate determination during stem cell differentiation
03
Disease associations
Other (no direct role confirmed in cancer, cardiovascular, or other major human diseases based on current literature; mainly studied in developmental biology contexts)
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