MicroRNA-1266 (miR-1266)

MicroRNA-1266 is a small, non-coding RNA molecule of approximately 20–24 nucleotides in length classified as a microRNA (miRNA)[1][6]. Like other miRNAs, miR-1266 participates in post-transcriptional gene regulation by binding the 3' untranslated region (UTR) of target mRNAs via imperfect base pairing, leading to translational repression or mRNA destabilization[1][6]. Functionally, miR-1266 has been shown to suppress cell growth, cell cycle progression, and metastasis, particularly in the context of gastric cancer and papillary thyroid carcinoma by targeting oncogenic transcripts including hTERT and FGFR2[1][3]. miR-1266 expression is found to be decreased in various tumor tissues compared to normal tissues, and its restoration can inhibit tumorigenic processes[3][5]. Thus, miR-1266 is considered both a regulator of gene expression and a potential tumor suppressor, with emerging utility as a cancer biomarker.

Other names

hsa-miR-1266hsa-mir-1266MIR1266MIRN1266mir-1266

Binds to the 3' untranslated region (UTR) of target mRNAs, such as hTERT and FGFR2, leading to inhibition of translation or mRNA degradation[1][3].