MicroRNA 127 (miR-127)

MicroRNA 127 (miR-127) is a short non-coding RNA (about 20-24 nucleotides) that regulates gene expression at the post-transcriptional level by binding to target mRNAs, leading to their degradation or inhibition of translation. It is expressed from the RTL1as gene and known to repress RTL1 through an RNAi mechanism. miR-127 is upregulated in cellular senescence, suppresses cell proliferation (by targeting proto-oncogenes such as BCL6), and regulates cell cycle proteins (p53, p21, cyclin D1). In glioblastoma, miR-127 (specifically miR-127-3p) promotes cell invasion and migration by targeting genes influencing cytoskeleton remodeling (e.g., SEPT7). Therapeutically, miR-127 mimics or prodrugs can inhibit tumor growth and metastasis, and its expression acts as a biomarker for various disease states. It also modulates immune responses by regulating gene expression in macrophages participating in inflammation. Safety concerns for therapeutic targeting center on delivery, specificity, and broad effects on gene networks.

Other names

MIR127miR-127hsa-mir-127MIRN127miRNA127mir-127

Most drugs/experimental therapies act as miR-127 mimics or prodrugs to restore/suppress its activity in disease contexts. These approaches aim to suppress oncogene expression (e.g., BCL6 in breast cancer) or alter invasion/migration genes (e.g., SEPT7 in glioblastoma).