MicroRNA 1284 (miR-1284)

MicroRNA 1284 (miR-1284) is a short non-coding RNA (20–24 nucleotides) classified as a microRNA, involved in the post-transcriptional regulation of gene expression by binding to target mRNAs, leading to inhibition of translation or mRNA destabilization[2]. miR-1284 has functional roles in the regulation of cell proliferation, apoptosis, and cell cycle progression, particularly in cancer contexts. Experimental studies demonstrate that miR-1284 inhibits growth and induces apoptosis in lung cancer cells, likely through the modulation of key proteins such as Myc, p27, Bax, and caspase-3[1]. Increased miR-1284 levels enhance chemosensitivity, including when co-delivered with cisplatin in experimental systems, suggesting a potential therapeutic target for overcoming drug resistance[4]. As a microRNA, miR-1284 is not a protein-coding gene, enzyme, or receptor, but rather a regulator with broad functional impact in post-transcriptional gene networks[1][2].

Other names

hsa-mir-1284MIRN1284MIR1284mir-1284

Modulation of chemosensitivity via enhancement of apoptosis when co-delivered with chemotherapeutic agents (e.g., cisplatin)[4]