MicroRNA 1287 (miR-1287 (also: miR-1287-5p))

MicroRNA 1287 (miR-1287; human: hsa-miR-1287) is a small, noncoding RNA approximately 20–25 nucleotides in length that functions through post-transcriptional silencing or degradation of target messenger RNAs by binding to their 3′ untranslated regions. miR-1287 has been implicated in several physiological and disease processes, including regulation of cell proliferation, apoptosis, ferroptosis (a type of iron-dependent cell death), inflammation, and likely acts in tumor suppression in some cancers such as osteosarcoma and lower grade gliomas. It may also play a role in modulating cytokine response in viral infections, such as COVID-19 through regulation of IL6R and other inflammatory mediators. miR-1287 and especially its mature form miR-1287-5p are being researched as diagnostic and prognostic biomarkers in various pathologies, as well as experimental targets for RNA-based therapeutics. No conventional small molecule drugs currently modulate miR-1287, but ongoing research explores oligonucleotide-based strategies.

Other names

hsa-miR-1287MIR1287MIRN1287hsa-mir-1287mir-1287miR-1287-5p

Antisense oligonucleotides could inhibit miR-1287 function (miRNA inhibition); miRNA mimics could restore miR-1287 function if downregulated; These approaches may alter expression of downstream target genes or affect pathways like ferroptosis or inflammation.