MicroRNA 1288 (MIR1288)

MicroRNA 1288 is a short non-coding RNA molecule (miRNA) classified within the miRNA family. It is transcribed, processed via Drosha and Dicer pathways, and then incorporated into the RNA-induced silencing complex (RISC), where it directs post-transcriptional regulation of target mRNAs. Expression of MIR1288 is reduced in many colorectal cancers compared to normal tissue and adenomas, and restoring its levels experimentally increases cell proliferation and drives cell cycle progression, indicating a complex role in cancer biology. MIR1288 is being investigated both for its functional role in cancer progression and as a potential therapeutic target or biomarker for patient stratification[1][2]. If you need more structured or technical details (e.g., sequence, genomic location, validated targets), please specify. MIR1288 is distinct from the closely related but genomically separate miRNA-128 family (such as miR-128-1 and miR-128-2)[2], which have been more extensively studied; MIR1288’s known direct molecular targets remain under active research.

Other names

hsa-mir-1288MIRN1288MIR1288hsa-miR-1288-5p (strand-specific)miRNA-1288

For drugs or experimental molecules (mimics/inhibitors): modulation of MIR1288 alters its suppression or activation of target mRNAs, thereby impacting cell proliferation and cycle progression