microRNA 1289 (miR-1289)

MicroRNA 1289 is a small, single-stranded non-coding RNA molecule encoded in the human genome. It acts as a post-transcriptional regulator by binding complementary sequences in the 3' UTRs of target mRNAs, leading to mRNA degradation or translational inhibition. miR-1289 has been identified as a tumor-suppressive microRNA, with strong growth-inhibitory effects on oral squamous cell carcinoma cells. Its expression is decreased in tumor tissue, and restoration via synthetic mimics suppresses tumor growth both in vitro and in animal models. Key mRNA targets include magnesium transporter 1 (MAGT1), cyclin E1 (CCNE1), GINS complex subunit 1 (GINS1), beclin 1 (BECN1), and dimethylarginine dimethylaminohydrolase 1 (DDAH1), all involved in cell cycle, autophagy, and metabolic regulation. There is emerging evidence that miR-1289 mediates additional biological processes associated with infection and mRNA sorting into microvesicles[2].

Other names

hsa-mir-1289-1MIR1289-1MIRN1289-1miR-1289

Synthetic miR-1289 mimics reduce cancer cell growth by binding to target mRNA 3' UTRs, causing degradation or translational repression of oncogenic or cell cycle-related genes (e.g., MAGT1, CCNE1, GINS1, DDAH1, BECN1)[2]. Restoration of miR-1289 expression enables tumor suppression in cancer cells[2].