MicroRNA 1289-2 (miR-1289-2)

MicroRNA 1289-2 is a small, noncoding RNA molecule that regulates gene expression by binding to complementary sequences within target mRNAs, resulting in their silencing or degradation. In human cancer biology, particularly oral squamous cell carcinoma, miR-1289-2 exhibits strong tumor suppressor functionality: its expression is reduced in malignant tissue, and restoration via synthetic mimics significantly inhibits tumor cell proliferation both in vitro and in animal models. miR-1289-2 directly targets key genes involved in cell growth and survival, with magnesium transporter 1 (MAGT1) being a principal functional target in OSCC. Early-stage therapeutic research positions miR-1289-2 as a promising molecular target for RNA-based or gene therapy approaches, pending further validation in broader cancer types and clinical studies[1][2].

Other names

hsa-mir-1289-2MIRN1289-2MIR1289-2miR-1289

Synthetic mimic substituting or restoring endogenous miR-1289 reduces tumor cell growth and represses target gene expression, notably magnesium transporter 1 (MAGT1)