MicroRNA 129-1 (miR-129-1)

MicroRNA 129-1 (miR-129-1) is a short, non-coding RNA molecule (microRNA) transcribed from the MIR129-1 gene on chromosome 7q32.1 in humans[3][5][10]. It regulates gene expression post-transcriptionally, primarily by binding to the 3'-untranslated region of target mRNAs to induce their degradation or inhibit their translation, acting via the RNA-induced silencing complex[3][10]. miR-129-1 has prominent biological roles in regulating cell proliferation, migration, apoptosis, and cell cycle, and exhibits tumor suppressor activity in multiple cancers[2][4][5][6]. Its aberrant (usually reduced) expression is linked to the pathogenesis of various malignancies as well as non-cancerous conditions such as heart failure, epilepsy, diabetes, and Alzheimer’s disease[5][7][9]. In addition, miR-129-1 contributes to neuronal migration and is expressed in the human brain, with enrichment in neurons during cortical development[7][9][11]. miR-129-1 (in its mature forms, miR-129-1-5p and miR-129-1-3p) is under intense investigation as a diagnostic and prognostic biomarker, especially for several cancer types, and as a potential therapeutic target for disease intervention[2][5][6].

Other names

hsa-mir-129-1MIR129-1MIR-129bMIRN129-1mir-129-1hsa-miR-129-1miR-129-1

Drugs (e.g., oligonucleotide mimics/anti-miRs) would modulate gene expression by restoring or inhibiting miR-129-1’s suppression of target mRNAs at the post-transcriptional level[2][5][6].