microRNA 1290 (miR-1290)

microRNA 1290 is a small non-coding RNA transcribed from the MIR1290 gene (chromosome 1p36.13). Its canonical mature sequence (MIMAT0005880) consists of 19 nucleotides. miR-1290 post-transcriptionally regulates multiple genes, including oncogenes and tumor suppressors (e.g., SOCS4, GSK3, BCL2, SCAI, INPP4B). It influences key signaling pathways—JAK/STAT3, PI3K/AKT, Wnt/β-catenin, and NF-κB—that drive cell proliferation, apoptosis, and metastasis in various cancers. Dysregulated expression of miR-1290 is consistently found in tumor tissue and circulating blood/exosomes of cancer patients, highlighting its utility as a diagnostic and prognostic biomarker. Therapeutic targeting of miR-1290 (by inhibition or modulation) is under preclinical investigation for its potential to suppress malignant cell behavior or sensitize tumors to chemotherapy. Beside cancer, miR-1290 has roles in cardiovascular protection, neuroregeneration, and tissue differentiation, further underscoring its pleiotropic biological functions.

Other names

hsa-mir-1290MIR1290MIRN1290

Drugs targeting miR-1290 generally aim to modulate its expression to impact cell proliferation, apoptosis, and sensitivity to chemotherapeutics.\nAntisense oligonucleotide strategies or inhibitors suppress miR-1290 activity, which can reverse oncogenic effects in cancer models.\nSome agents increase miR-1290 expression to induce apoptosis or alter chemosensitivity in tumor cells.