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Target intelligence / Profile preview
MicroRNA 1295a (MIR1295A)
- Target
- MIR1295A
- Molecular classification
- MicroRNA, Non-coding RNA, Small RNA
01
Overview
MicroRNA 1295a (MIR1295A) is a short (20–24 nucleotide) non-coding RNA molecule that regulates gene expression at the post-transcriptional level by base pairing with messenger RNAs (mRNAs) to inhibit translation or promote mRNA degradation. Like other miRNAs, MIR1295A is transcribed by RNA polymerase II, processed by the Drosha and Dicer enzymes, and incorporated into the RNA-induced silencing complex (RISC) to modulate target mRNAs. Its altered expression, along with other miRNAs, is implicated in the regulation of critical biological processes and may contribute to disease states, especially various cancers, by affecting gene regulatory networks.
- Other names
- hsa-mir-1295aMIR1295MIRN1295microRNA 1295hsa-mir-1295mir-1295aMIR1295A
02
Biological functions
Post-transcriptional regulation of gene expressionRegulation of mRNA stabilityTranslational inhibitionRegulation of cellular processes
03
Disease associations
Cancer (role suggested by general miRNA research; direct data on MIR1295A is limited, but differentially expressed miRNAs are key in tumorigenesis and cancer progression)Other (general functions of miRNAs in disease, but specific data on MIR1295A is lacking)
04
Safety considerations
None specific to MIR1295A (Challenges common to miRNA therapeutics include off-target effects and delivery, but no specific safety data for MIR1295A)
05
Biomarkers
Potentially a biomarker in cancer diagnostics (based on general miRNA utility in oncology), but no specific validated biomarker role for MIR1295A is established in current literature
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