MicroRNA-1301 (miR-1301)

MicroRNA-1301 (miR-1301) is a small, non-coding RNA molecule that regulates gene expression by binding to complementary sequences in the 3'-untranslated regions (UTRs) of target messenger RNAs (mRNAs), facilitating their degradation or translational inhibition. Its expression is dysregulated in a variety of human cancers, where it may act as either an oncogene or a tumor suppressor depending on cell type and context. miR-1301 modulates cell proliferation, cell cycle progression, migration, invasion, and apoptotic pathways by targeting multiple oncogenic or tumor suppressive proteins including N-Ras, SFRP1, GSK3β, SIRT1, Thy-1, among others. The abundance of miR-1301 in cancer tissues is associated with clinical parameters and prognosis, and pharmacological modulation of miR-1301 activity alters the effectiveness of certain chemotherapeutic agents.

Other names

MIR1301hsa-mir-1301mir-1301miR-1301-3pmicroRNA-1301

Antagonists/inhibitors of miR-1301: Block its function, restoring expression of downstream tumor-suppressing genes. miR-1301 mimics: Enhance its activity where it acts as a tumor suppressor. Competing endogenous RNA (ceRNA) strategies: Sponge or decoy miRNAs to modulate cellular effects. Drug effects on chemosensitivity are through modulation of miR-1301 levels in cancer contexts.