MicroRNA 130b-5p (miR-130b-5p)

MicroRNA 130b–5p is a short non-coding RNA molecule belonging to the microRNA class. It functions primarily by binding target messenger RNAs (mRNAs) through imperfect base pairing, leading to translational inhibition or destabilization of the target mRNAs. The mature form is generated from a stem-loop precursor processed by Drosha and Dicer enzymes. MiR‑130b–5p has been implicated in post-transcriptional gene regulation across various biological processes. Elevated levels are associated with several cancers—including hepatocellular carcinoma—where it serves as both a potential diagnostic/prognostic biomarker and an experimental therapeutic target. Inhibition of circulating miR‑130b–5p has shown promise in reducing tumor growth in preclinical studies, highlighting its relevance as an emerging molecular target for cancer therapy[1][3].

Other names

MIR130Bhsa-miR-130b-5pmiR-130b (sometimes used generically for both -3p and -5p strands)[3][7]

Experimental approaches include inhibition of miR‑130b‑5p using antisense oligonucleotides or nanoparticle-based delivery to suppress its oncogenic effects in cancer models.