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Target intelligence / Profile preview
microRNA-132 (miR-132)
- Target
- miR-132
- Molecular classification
- microRNA, non-coding RNA
01
Overview
MicroRNA-132 (miR-132) is a highly conserved, short non-coding RNA molecule that plays a critical regulatory role in gene expression, primarily by binding to target mRNAs and inhibiting their translation or promoting their degradation. It is involved in various biological processes including neuronal development, synaptic transmission, inflammation, and angiogenesis. Dysregulation of miR-132 is implicated in Alzheimer's disease and other neurological disorders.
- Other names
- microRNA 132
02
Mechanism of action
Binds to complementary sequences in target mRNAs, leading to translational repression or mRNA degradation.
03
Biological functions
Post-transcriptional gene silencingNeural developmentSynaptic plasticityInflammation regulationAngiogenesis regulationRegulation of cell cycle progressionPromotion of apoptosis
04
Disease associations
Alzheimer's DiseaseNeurodevelopmental disordersNeurodegenerative diseasesFragile X syndromeDepressionAnxiety disorders
05
Safety considerations
Overexpression can lead to cognitive deficitsDeficiency can lead to cognitive deficitsUpregulation can suppress excessive inflammation but may also impair antibacterial host defenses
06
Biomarkers
Downregulated in Alzheimer's Disease brainsLevels correlated with cognitive performance in Alzheimer's DiseasePotential biomarker for CNS diseases
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