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Target intelligence / Profile preview
MicroRNA 133a-2 (miR-133a-2)
- Target
- miR-133a-2
- Molecular classification
- MicroRNA, Non-coding RNA, Regulatory RNA, Other
01
Overview
MicroRNA 133a-2 (miR-133a-2) is a small, non-coding RNA molecule encoded in the human genome, classified as a microRNA. It functions as a regulator of gene expression by binding to the 3' untranslated regions of target mRNAs, thereby leading to inhibition of mRNA translation or mRNA destabilization. MiR-133a-2, whose mature sequence is identical to that of miR-133a-1, plays important roles in both physiological and pathological contexts, most notably as a tumor suppressor in a variety of cancers and as a regulator of cardiac and skeletal muscle development. Its downregulation is frequently observed in cancer tissues, where it is associated with increased tumor proliferation and poor prognosis. It also participates in regulating cardiac hypertrophy and arrhythmias, and its expression is altered in cardiac and muscular diseases. Due to its diagnostic and prognostic value, miR-133a-2 is studied as a noninvasive biomarker in liquid biopsies for early cancer detection and disease monitoring[1][2][3][4].
- Other names
- MIR133A2hsa-mir-133a-2MIRN133A2mir-133a-2
02
Biological functions
Post-transcriptional gene silencingRegulation of cell proliferationRegulation of apoptosisCell differentiation (notably in muscle tissue)Tumor suppressionCardiac and skeletal muscle development
03
Disease associations
Cancer (multiple types including colorectal, breast, lung, bladder, gastric, osteosarcoma, etc.)Cardiovascular disease (e.g., cardiac hypertrophy, heart failure, arrhythmia)Neurodegenerative disease (supported by association with Parkinson's disease)Muscular dystrophy
04
Safety considerations
Potential for off-target gene regulation if used therapeuticallyPossible unintended effects due to broad regulation of multiple gene networks
05
Biomarkers
Prognostic and early diagnostic marker for multiple cancers (e.g., colorectal, NSCLC, gastric)Marker for tumor hypoxia and aggressive/metastatic behaviorMarker for cardiac muscle disease states
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