Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
microRNA-134 (miR-134)
- Target
- miR-134
- Molecular classification
- Non-coding RNA, MicroRNA
01
Overview
microRNA-134 (miR-134) is a small, noncoding RNA molecule that regulates gene expression post-transcriptionally by binding to complementary sequences on target messenger RNAs (mRNAs), leading to their degradation or translational repression. In neurons, miR-134 modulates dendritic spine development and synaptic strength. Outside the nervous system, miR‑134 acts predominantly as a tumor suppressor.
- Other names
- hsa-miR-134MIR134
02
Mechanism of action
Post-transcriptional repression/degradation via RISC
03
Biological functions
Post-transcriptional gene regulationRegulation of dendritogenesisRegulation of synaptic plasticityRegulation of neural excitabilityTumor suppression
04
Disease associations
EpilepsyTemporal lobe epilepsyGastric cancerGlioma/Glioblastoma multiforme (GBM)Breast cancerOsteosarcomaNon-small cell lung cancer
05
Safety considerations
Off-target effects of antisense oligonucleotidesPotential disruption of normal neuronal development with miR-134 modulationComplex and context-dependent role in tumorigenesis
06
Interacting drugs
Antisense oligonucleotides targeting miR-134
1 more in the full profile.
07
Biomarkers
miR-134 expression levels in epilepsy patientsmiR-134 expression levels in cancer patients
Beyond the preview
Go deeper on microRNA-134 (miR-134).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on microRNA-134 (miR-134).