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Target intelligence / Profile preview
MicroRNA-145 (miR-145)
- Target
- miR-145
- Molecular classification
- microRNA
01
Overview
MicroRNA-145 is a small non-coding RNA molecule that regulates gene expression at the post-transcriptional level. It is involved in normal blood cell development and is a tumor suppressor in various cancers. miR-145 targets multiple oncogenes and signaling pathways, influencing tumor growth, invasion, and metastasis. Its expression is often reduced in cancer tissues, making it a potential diagnostic and therapeutic target.
- Other names
- miR-145MIR145
02
Mechanism of action
Regulation of oncogene expression; Inhibition of cell cycle progression; Promotion of apoptosis; Modulation of signaling pathways.
03
Biological functions
Regulation of gene expressionCell cycle regulationProliferation controlApoptosis regulationDifferentiation regulationStress response regulation
04
Disease associations
Cancer (tumor suppressor role in various cancers)Vascular disease (involvement in vascular health)Coronary artery anomalies
05
Safety considerations
miR-145's role in both tumor suppression and potential pro-metastatic effects in certain cancers requires careful consideration in therapeutic strategies.
06
Biomarkers
Potential biomarker for cancer diagnosis and prognosis
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